Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders. Over the years, it has become clear that melatonin may exacerbate some autoimmune conditions, whereas it alleviates others such as multiple sclerosis. Multiple sclerosis is an autoimmune disorder characterized by a dysregulated immune response directed against the central nervous system. Indeed, the balance between pathogenic CD4+ T cells secreting IFN‐γ (TH1) or IL‐17 (TH17); and FoxP3+ regulatory T cells and IL‐10+ type 1 regulatory T cells (Tr1 cells) (...) is thought to play an important role in disease activity. Recent evidence suggests that melatonin ameliorates multiple sclerosis by controlling the balance between effector and regulatory cells, suggesting that melatonin‐triggered signaling pathways are potential targets for therapeutic intervention. Here, we review the available data on the effects of melatonin on immune processes relevant for MS and discuss its therapeutic potential. (shrink)

Human beings think of themselves in terms of a privileged non-descriptive designator — a mental “I”. Such thoughts are called “de se” thoughts. The mind/body problem is the problem of deciding what kind of thing I am, and it can be regarded as arising from the fact that we think of ourselves non-descriptively. Why do we think of ourselves in this way? We investigate the functional role of “I” (and also “here” and “now”) in cognition, arguing that the use of (...) such non-descriptive “reflexive” designators is essential for making sophisticated cognition work in a general-purpose cognitive agent. If we were to build a robot capable of similar cognitive tasks as humans, it would have to be equipped with such designators. Once we understand the functional role of reflexive designators in cognition, we will see that to make cognition work properly, an agent must use a de se designator in specific ways in its reasoning. Rather simple arguments based upon how “I” works in reasoning lead to the conclusion that it cannot designate the body or part of the body. If it designates anything, it must be something non-physical. However, for the purpose of making the reasoning work correctly, it makes no difference whether “I” actually designates anything. If we were to build a robot that more or less duplicated human cognition, we would not have to equip it with anything for “I” to designate, and general physicalist inclinations suggest that there would be nothing for “I” to designate in the robot. In particular, it cannot designate the physical contraption. So the robot would believe “I exist”, but it would be wrong. Why should we think we are any different? (shrink)

: I’m going to generalize the points that L.A. Paul makes in her Transformative Experience and push them in a somewhat different direction. I will begin by talking about transformative experience in a generic sense and say how ubiquitous it is. Then I’ll distinguish that from the strict, specialized sense of transformative experience that Paul identifies. I will say why Paul’s focus on the strict and specialized sense allows her to arrive at a strong conclusion, but bypasses the more interesting (...) lessons which concern the importance of de se imagination and the possibilities for educating it. Keywords: Transformative Experience; Laurie A. Paul; Imagination; Decision Esperienza, trasformazione, immaginazione Riassunto: Intendo generalizzare le questioni sollevate da L.A. Paul nel suo Trasformative Experience, spingendole in una direzione differente. Inizierò parlando dell’esperienza trasformativa in senso generico, illustrando quanto questa sia diffusa. Quindi distinguerò questo senso generico di esperienza trasformativa da quello più ristretto identificato da Paul. Illustrerò poi le ragioni per cui la messa a fuoco di questo senso ristretto e specifico da parte di Paul le consente di giungere a conclusioni forti, evitando però i compiti più interessanti che riguardano l’importanza dell’immaginazione de se e le possibilità di educarla. Parole chiave: Esperienza trasformativa; Laurie A. Paul; Immaginazione; Decisione. (shrink)

Funding agencies and large public scientific institutions are increasingly using the term “research portfolio” as a means of characterizing their research. While portfolios have long been used as a heuristic for managing corporate R&D, they remain ill-defined in a science policy context where research is aimed at achieving societal outcomes. In this article we analyze the discursive uses of the term “research portfolio” and propose some general considerations for their application in science policy. We explore the use of the term (...) in private R&D and related scholarly literature in existing science policy practices, and seek insight in relevant literature in science policy scholarship. While the financial analogy can in some instances be instructive, a simple transposition from the world of finance or of corporate R&D to public research is problematic. However, we do identify potentially fruitful uses of portfolio analysis in science policy. In particular, our review suggests that the concept of research portfolio can indeed be a useful analytical instrument for tackling complex societal challenges. Specifically, the strands of scholarship identified suggest that the use of research portfolio should: i) recognize the diversity of research lines relevant for a given societal challenge, given the uncertainty and ambiguity of research outcomes; ii) examine the relationships between research options of a portfolio and the expected societal outcomes; and iii) adopt a systemic perspective to research portfolios – i.e. examine a portfolio as a functional whole, rather than as the sum of its parts. We argue that with these considerations, portfolio-driven approaches may foster social inclusion in science policy decisions, help deliberation between “alternative” portfolios to tackle complex societal challenges, as well as promote cost-effectiveness and transparency. (shrink)

Nous proposons ci-après l’étude de la relation entre science et spiritualité chez Georges Lemaître, savant et croyant, un des acteurs principaux de la fondation de la cosmologie moderne. Il s’agit d’explorer la nature et le rôle de cette relation lors d’un épisode important de l’histoire des sciences, plus généralement de l’histoire de la pensée. Le mot spiritualité est ici entendu au sens suivant : l’idée et la recherche du divin, du vrai. Il résulte de la présente approche une appréhension élargie (...) de la prime histoire de la théorie dite du « big bang ». (shrink)

The aim of this work is to evaluate the role played by Alfonso Luis Herrera and Isaac Ochoterena in the institutionalization of academic biology in Mexico in the early 20th century. As biology became institutionalized in Mexico, Herrera's basic approach to biology was displaced by Isaac Ochoterena's professional goals due to the prevailing political conditions at the end of 1929. The conflict arose from two different conceptions of biology, because Herrera and Ochoterena had different discourses that were incommensurable, not only (...) linguistically speaking, but also socioprofessionally. They had different links to influential groups related to education, having distinct political and socioprofessional interests. The conflict between Herrrera and Ochoterena determined the way in which professional biology education has developed in Mexico, as well as the advancement in specific research subjects and the neglect of others. (shrink)

The study of the psychological effects of social media use on adolescents’ adjustment has long been the focus of psychological research, but results are still inconclusive. In particular, there is a lack of research on the positive and negative developmental outcomes and on possible moderating variables, especially concerning early adolescence. To fill these gaps in literature, the present study longitudinally investigated the relationships between social media use, depressive symptoms, affective well-being and life satisfaction, as well as the moderating role of (...) emotional self-efficacy and gender. The study involved 336 Italian early adolescents who completed an anonymous self-report questionnaire twice within a year. Main results showed that higher social media use was related to higher depressive symptoms, lower affective well-being and lower life satisfaction among girls with lower emotional self-efficacy. Conversely, high social media use was related to higher affective well-being and higher life satisfaction for girls with higher emotional self-efficacy. Results are discussed in relation to their implications for risk prevention and health promotion among early adolescents. In particular, our results suggest that promoting emotional self-efficacy can be very helpful in making the use of social media an opportunity for well-being and life satisfaction rather than a developmental risk. (shrink)

The diagnosis of a chronic illness during young adulthood represents a non-normative life transition influencing the identity definition process, as well as the individual psychological adjustment. The study examined if relationships between identity motives (self-esteem, efficacy, continuity, distinctiveness, belonging, and meaning), health-related quality of life, and depressive symptoms differ between healthy young adults and young adults diagnosed with multiple sclerosis (MS). Two hundred one people (101 MS patients and 100 healthy controls), aged 18–35 years, completed a self-report questionnaire. Young adults (...) with MS reported lower health-related quality of life and lower efficacy motive than their healthy peers. Among MS patients, high meaning was related to lower depressive symptoms, whereas high continuity and high belonging were related to higher health-related quality of life than in healthy controls. The study highlights the relevance of identity motives for the adjustment to MS and has implications for psychological interventions with young patients. (shrink)

What methodology should philosophers follow? Should they rely on methods that can be conducted from the armchair? Or should they leave the armchair and turn to the methods of the natural sciences, such as experiments in the laboratory? Or is this opposition itself a false one? Arguments about philosophical methodology are raging in the wake of a number of often conflicting currents, such as the growth of experimental philosophy, the resurgence of interest in metaphysical questions, and the use of formal (...) methods. This outstanding collection of specially-commissioned chapters by leading international philosophers discusses these questions and many more. It provides a comprehensive survey of philosophical methodology in the most important philosophical subjects: metaphysics, epistemology, philosophy of language, philosophy of mind, phenomenology, philosophy of science, ethics, and aesthetics. A key feature of the collection is that philosophers discuss and evaluate contrasting approaches in each subject, offering a superb overview of the variety of methodological approaches - both naturalistic and non-naturalistic - in each of these areas. They examine important topics at the heart of methodological argument, including the role of intuitions and conceptual analysis, thought experiments, introspection, and the place that results from the natural sciences should have in philosophical theorizing. The collection begins with a fascinating exchange about philosophical naturalism between Timothy Williamson and Alexander Rosenberg, and also includes contributions from the following philosophers: Lynne Rudder Baker, Matt Bedke, Greg Currie, Michael Devitt, Matthew C. Haug, Jenann Ismael, Hilary Kornblith, Neil Levy, E.J. Lowe, Kirk Ludwig, Marie McGinn, David Papineau, Matthew Ratcliffe, Georges Rey, Jeffrey W. Roland, Barry C. Smith, Amie L. Thomasson, Valerie Tiberius, Jessica Wilson, and David W. Smith. (shrink)

In 1687 Isaac Newton ushered in a new scientific era in which laws of nature could be used to predict the movements of matter with almost perfect precision. Newton's physics also posed a profound challenge to our self-understanding, however, for the very same laws that keep airplanes in the air and rivers flowing downhill tell us that it is in principle possible to predict what each of us will do every second of our entire lives, given the early conditions of (...) the universe. Can it really be that even while you toss and turn late at night in the throes of an important decision and it seems like the scales of fate hang in the balance, that your decision is a foregone conclusion? Can it really be that everything you have done and everything you ever will do is determined by facts that were in place long before you were born? This problem is one of the staples of philosophical discussion. It is discussed by everyone from freshman in their first philosophy class, to theoretical physicists in bars after conferences. And yet there is no topic that remains more unsettling, and less well understood. If you want to get behind the façade, past the bare statement of determinism, and really try to understand what physics is telling us in its own terms, read this book. The problem of free will raises all kinds of questions. What does it mean to make a decision, and what does it mean to say that our actions are determined? What are laws of nature? What are causes? What sorts of things are we, when viewed through the lenses of physics, and how do we fit into the natural order? Ismael provides a deeply informed account of what physics tells us about ourselves. The result is a vision that is abstract, alien, illuminating, and-Ismael argues-affirmative of most of what we all believe about our own freedom. Written in a jargon-free style, How Physics Makes Us Free provides an accessible and innovative take on a central question of human existence. (shrink)

J. T. Ismael's monograph is an ambitious contribution to metaphysics and the philosophy of language and mind. She tackles a philosophical question whose origin goes back to Descartes: What am I? The self is not a mere thing among things--but if so, what is it, and what is its relationship to the world? Ismael is an original and creative thinker who tries to understand our problematic concepts about the self and how they are related to our use of (...) language in particular. (shrink)

Quantum mechanics seems to portray nature as nonseparable, in the sense that it allows spatiotemporally separated entities to have states that cannot be fully specified without reference to each other. This is often said to implicate some form of “holism.” We aim to clarify what this means, and why this seems plausible. Our core idea is that the best explanation for nonseparability is a “common ground” explanation, which casts nonseparable entities in a holistic light, as scattered reflections of a more (...) unified underlying reality. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 177 Amsterdam, appears in the series of the International Archives of the History of Ideas, published under the direction of P. Dibon of Nijmegen and R. Popkin of the University of California at San Diego and a distinguished international editorial committee. Other volumes demonstrate the philosophical respectability of the collection: three on Descartes and Cartesianism, one on Berkeley's immaterialism, three on Pierre Bayle, the rest on philosophical (...) topics from the Renaissance to the 19th century. In this gallery, these letters by a not very good French poet---who was yet an acute and rather individualistic judge of men and books, already one of the arbiters of intellectual and artistic life in France--may seem a little out of place. Yet, to many historians of intellectual affairs, the firm establishment of dates and personal relationships is a matter of much importance, and documents such as these, largely devoted as they are to the communication of news about books and writers, the activities of rulers and ambassadors, printers and curious travelers, can be a substantial aid in determining the structure of an historical moment, the succession and interrelationship of events. One is willing to grant that much of what Chapelain wrote to Heinsius is trivial and concerns books and literary news of slight importance, that a delicate irony makes less of some of his comments than they were worth at the time. The triviality itself is a clue to the temper of Paris during the Fronde and in the late years of the regency of Mazarin. Great ideas were not being discussed in public when Pascal was writing his Pensdes; the irony is a mode of defense against involvement, and fashionable at the time. Bray's elaborate introduction is more concerned with the artistic and subjective aspect of the letters than with their contribution to intellectual history. In about a hundred pages, he discusses his author's method of writing, the genre which this kind of letter represents, the artistry it exhibits, from basic structure to stylistic ornamentation, and finally the human and even ethical implications of this collection. His notes are full and informative; identifications are well documented and cross-referencing in the notes and in the index of names make the volume a usable source of information, even though it cannot be recommended as stimulating debate or lively narrative. The topics discussed by Chapelain range over a considerable area, without becoming controversial. There is one exceptional letter in which he instructs Heinsius in adapting his integrity to the role of a diplomat; he must acquire "un peu de dissimulation" to oppose to "l'ing~nuit~ du Parnasse." There are references to civil strife, to foreign affairs, to the rivalry of Dutch and English navies, to the sympathy of the French for the Swedish Lutheran dynasty as opposed to the Catholic ttapsburgs and the ecclesiastical electors of Mainz, Cologne, and Trier. Queen Christina of Sweden plays a continually less attractive part as the letters proceed to their end; and Christiaan Huygens, the Duc de Montausier, Ismael Boulliau, Guez de Balzac, and Gilles M4nage figure more or less regularly in these pages. Of philosophers there is little mention, and of discussion of ideas for their own sake still less. The letters are, like many another collection deriving from the age before the learned and scientific journals, a source of valuable information about certain persons and certain books; they are hardly a serious contribution to the history of ideas. H~covaT BROWN Brown University Pascal. By J. H. Broome. (New York: Barnes & Noble, Inc., 1966. pp. x + 250. $6.00.) The most remarkable feature of this work is that it locates and forcefully interprets philosophical themes common to all of Pascal's widely=diversified writing. In his works on the vacuum, the computer, geometry, hydrostatics, Grace, freedom and the art of persuasion as well as the Pens~es, Broome locates five regular features of Pascal's thought: 1) the three orders (pp. 103-4, inter alia); 2) the deux infinis (p. 146); 3) a theory of knowl- 178 HISTORY OF PHILOSOPHY edge; 4) a dialecticalmethod; and 5) a theory of communication. The former two themes are commonly discussed by students of... (shrink)

The role of probability is one of the most contested issues in the interpretation of contemporary physics. In this paper, I’ll be reevaluating some widely held assumptions about where and how probabilities arise. Larry Sklar voices the conventional wisdom about probability in classical physics in a piece in the Stanford Online Encyclopedia of Philosophy, when he writes that “Statistical mechanics was the first foundational physical theory in which probabilistic concepts and probabilistic explanation played a fundamental role.” And the conventional wisdom (...) about quantum probabilities is that they are basic, not reducible to the types of probabilities we see in statistical mechanics. In the first section of this paper, I’ll argue that in fact classical physics was steeped in probability long before statistical mechanics came on the scene, specifically, that an objective measure over phase space is an indispensable component of any informative physical theory. In the next section, I’ll argue that this objective measure is the fundamental form of physical probability and that quantum probabilities can be defined in terms of it. In the last, I’ll raise some questions about the metaphysical status of the fundamental measure. (shrink)

J. T. Ismael's monograph is an ambitious contribution to metaphysics and the philosophy of language and mind. She tackles a philosophical question whose origin goes back to Descartes: What am I? The self is not a mere thing among things--but if so, what is it, and what is its relationship to the world?

Huw Price has argued that on an interventionist account of cause the distinction is perspectival, and the claim prompted some interesting responses from interventionists and in particular an exchange with Woodward that raises questions about what it means to say that one or another structure is perspectival. I’ll introduce his reasons for claiming that the distinction between cause and effect on an interventionist account is perspectival. Then I’ll introduce a distinction between different ways in which a class of concepts can (...) be said to depend on facts about their users. Three importantly different forms of dependence will emerge from the discussion: Pragmatic dependence on us: truth conditions for x-beliefs can be given by a function f \ of more fundamental physical structures making no explicit reference to human agents. But there are any other number of functions ) ontologically on a par with x and what explains the distinguished role f plays in our practical and epistemic lives are facts about us. Implicit relativization: truth conditions for x-beliefs are relative to agent or context; the context supplies the value of a hidden parameter that determines the truth of x-beliefs. Indexicals: like implicit relativization except that the surface syntax contains a term whose semantic value is context-dependent. I suggest that Price’s insights are best understood in the first way. This will draw a crucial disanalogy with his central examples of perspectival concepts, but it will refine the thesis in a way that is more faithful to what his arguments show. The refined thesis will also support generalization to other concepts, and clarify the foundations of the quite distinctive research program that Price has been developing for a number of years. (shrink)

Before the twentieth century, the Universe was usually imagined as a large spatially extended thing unfolding in time. The past was fixed and the future was open; unfolding was conceived as an asymmetric process of coming into being. Relativity introduced a new vision in which space and time are presented together as a single four-dimensional manifold of events. That, together with the fact that the fundamental laws of our classical theories are symmetric in time, made understanding why the past and (...) future present themselves so differently in our experience one of the central challenges of physics. The last two centuries have seen a great deal of progress in understanding various of the so-called arrows of time: the thermodynamic arrow, the cosmological arrow, the arrow of knowledge or information. There remains an outstanding piece of this puzzle that has seen little progress, one that Roger Penrose described in his beautiful paper Singularities and Time-Asymmetry in 1979 as: “The arrow most difficult to comprehend … namely the feeling of relentless forward temporal progression, according to which potentialities seem to be transformed into actualities.”I will propose that the insight needed to resolve the problem involves taking into account that we are part of the universe and that any attempt to model it as a totality involves self-reference. I will argue specifically that self-reference, against the background of a thermodynamic gradient, creates an instability in an embedded agent’s ability to know the future or even treat it as a potential object of knowledge. That instability captures the sense in which the future remains for her perpetually open and the passage of time resolves openness into the fixity of fact. (shrink)

First para: Before the 17th century, there was not much discussion, and little uniformity in conception, of natural laws. The rise of science in 17th century, Newton’s mathematization of physics, and the provision of strict, deterministic laws that applied equally to the heavens and to the terrestrial realm had a profound impact in transforming the philosophical imagination. A philosophical conception of physical law built on the example of Newtonian Mechanics became quickly entrenched. Between the 17th and 20th centuries, there was (...) a great deal of philosophical interest in probabilities, but probabilities were mostly regarded as having something to do with the management of opinion, not as having a fundamental role in science. Probabilities made their first appearance in an evidently ineliminable way in the laws of a fundamental theory with the advent of quantum mechanics. Quantum probabilities have come to be called ‘chances’ in the philosophical literature, and their interpretation has been one of the central problems in philosophy of science now for almost a century. There continue to be hold-outs that insist that there must be an underlying probability-free replacement for quantum mechanics and Bohmians have had some success in formulating a deterministic alternative to quantum mechanics, but most physicists accept that the probabilistic character of the quantum mechanical laws is likely to be retained in any successor theory. While physics has adjusted itself comfortably to the existence of ineliminably probabilistic laws, philosophy has not managed arrive at a stable interpretation of quantum probability. The difficulty is that there are a number of constraints that an interpretation of chance must satisfy, constraints that appear to be partially definitive of the concept and it proves to be extraordinarily difficult to meet them simultaneously. (shrink)

Dennett’s story “Where am I?” is used to set up the difficulty of locating the self in the natural world. The story is told from a first-person point of view in which the narrator maintains his identity across exchanges of brain and body, but there is no physical thing in the story that can act as bearer of his identity. The story seems to present a dilemma between Cartesian dualism and Dennett’s a “no-self” view. This chapter argues for a third (...) option. Prepersonal processes in the brain stabilize separable conceptions of self and world out of patterns in sensory information. The conception of self starts out as a mere sensorimotor point of view but gradually develops into something richer. Seeing how the first-person point of view arises is seeing how the self arises, because the self is nothing but the proper subject of a first-person point of view. (shrink)

In this paper, I defend an empiricist account of modality that keeps a substantive account of modal commitment, but throws out the metaphysics. I suggest that if we pair a deflationary attitude toward representation with a substantive account of how scientific models are constructed and put to use, the result is an account that deflates the metaphysics of modal commitment without deflating the content of modal claims.

In a famous passage drawing implications from determinism, Laplace introduced the image an intelligence who knew the positions and momenta of all of the particles of which the universe is composed, and asserted that in a deterministic universe such an intelligence would be able to predict everything that happens over its entire history. It is not, however, difficult to establish the physical possibility of a counterpredictive device, i.e., a device designed to act counter to any revealed prediction of its behavior. (...) What would happen if a Laplacean intelligence were put into communication with such a device and forced to reveal its prediction of what the device would do on some occasion? On the one hand, it seems that the Laplacean Intelligence should be able to predict the device's behavior. On the other hand, it seems like that device should be able to act counter to the prediction. An examination of the puzzle leads to clarification of what determinism does entail, with some insights about various other things along the way. (shrink)

This chapter addresses the worry that the existence of causal antecedents to your choices means that you are causally compelled to act as you do. It begins with the folk notion of cause, leads the reader through recent developments in the scientific understanding of causal concepts, and argues that those developments undermine the threat from causal antecedents. The discussion is then used as a model for a kind of naturalistic metaphysics that takes its lead from science, letting everyday concepts be (...) shaped and transformed by scientific developments. (shrink)

The most potentially powerful objection to the possibility oftime travel stems from the fact that it can, under the right conditions, give rise to closedcausal loops, and closed causal loops can be turned into self-defeating causal chains;folks killing their infant selves, setting out to destroy the world before they were born,and the like. It used to be thought that such chains present paradoxes; the receivedwisdom nowadays is that they give rise to physical anomalies in the form of inexplicably correlated events. (...) I argue against the received wisdom. I can find nothing in them that argues against the possibility (even, the probability) of time travel. (shrink)

The chance of a physical event is the objective, single-case probability that it will occur. In probabilistic physical theories like quantum mechanics, the chances of physical events play the formal role that the values of physical quantities play in classical physics, and there is a temptation to regard them on the model of the latter as describing intrinsic properties of the systems to which they are assigned. I argue that this understanding of chances in quantum mechanics, despite being a part (...) of the orthodox interpretation of the theory and the most prevalent view in the physical community, is incompatible with a very wide range of metaphysical views about the nature of chance. The options that remain are unlikely to be attractive to scientists and scientifically minded philosophers. (shrink)

:Rawls ignited a debate in political theory when he introduced a division between the ideal and nonideal parts of a theory of justice. In the ideal part of the theory, one presents a positive conception of justice in a setting that assumes perfect compliance with the rules of justice. In the nonideal part, one addresses the question of what happens under departures from compliance. Critics of Rawls have attacked his focus on ideal theory as a form of utopianism, and have (...) argued that political theory should be focused instead on providing solutions to the manifest injustices of the real world. In this essay, I offer a defense of the ideal/nonideal theory distinction according to which it amounts to nothing more than a division of labor, and explore some scientific analogies. Rawls’s own focus on the ideal part of the theory, I argue, stems from a felt need to clarify the foundations of justice, rather than a utopian neglect of real world problems. (shrink)

Quantum mechanics is, at least at first glance and at least in part, a mathematical machine for predicting the behaviors of microscopic particles — or, at least, of the measuring instruments we use to explore those behaviors — and in that capacity, it is spectacularly successful: in terms of power and precision, head and shoulders above any theory we have ever had. Mathematically, the theory is well understood; we know what its parts are, how they are put together, and why, (...) in the mechanical sense (i.e., in a sense that can be answered by describing the internal grinding of gear against gear), the whole thing performs the way it does, how the information that gets fed in at one end is converted into what comes out the other. The question of what kind of a world it describes, however, is controversial; there is very little agreement, among physicists and among philosophers, about what the world is like according to quantum mechanics. Minimally interpreted, the theory describes a set of facts about the way the microscopic world impinges on the macroscopic one, how it affects our measuring instruments, described in everyday language or the language of classical mechanics. Disagreement centers on the question of what a microscopic world, which affects our apparatuses in the prescribed manner, is, or even could be, like intrinsically ; or how those apparatuses could themselves be built out of microscopic parts of the sort the theory describes.[1.. (shrink)

The Hard Problem of the mind is addressed and it is argued that physical-phenomenal property identities have the same status as the identification of an ostended bit of physical space and the coordinates assigned the spot on a map of the terrain. It is argued, that is to say, that such identities are, or follow from, stipulations which interpret the map.

A reading is given of Curie''s Principle that the symmetry of a cause is always preserved its effects. The truth of the principle is demonstrated and its importance, under the proposed reading, is defended.As far as I see, all a priori statements in physics have their origin in symmetry. (Weyl, Symmetry, p. 126).

This chapter begins with a discussion of Dennett's view of self-representation. It introduces the so-called “Joycean Machine”, special narrative module in the brain charged with production of an autobiography. It is argued that the synchronic unity of the thinking subject is the unity of voice and agency wrought by the unifying activity of the Joycean Machine. In dynamical terms, the collective voice can have a causal role. Turned outward, it can mediate the communication between systems, allowing them to act as (...) unified agents in interaction with one another. Turned inward, it can govern the activity of the components. (shrink)

I want to consider some features of the position put forward by Julian Barbour in The End of Time that seem to me of particular philosophical interest. At the level of generality at which I'll be concerned with it, the view is relatively easy to describe. It can be arrived at by thinking of time as decomposing in some natural way linearly ordered atomic parts, ‘moments’, and combining an observation about the internal structure of moments with an epistemological doctrine about (...) our access to the past. The epistemological doctrine, which I'll call ‘Presentism’, following Butterfield, is the view that our access to the past is mediated by records, or local representations, of it. The observation is that the state of the world at any moment has the structure of what Barbour calls a ‘time capsule’, which is to say that it constitutes a partial record of its past, it is pregnant with interrelated mutually consistent representations of its own history. (shrink)

I propose, in the context of Everett interpretations of quantum mechanics, a way of understanding how there can be genuine uncertainty about the future notwithstanding that the universe is governed by known, deterministic dynamical laws, and notwithstanding that there is no ignorance about initial conditions, nor anything in the universe whose evolution is not itself governed by the known dynamical laws. The proposal allows us to draw some lessons about the relationship between chance and determinism, and to dispel one source (...) of the tendency among Everettians to introduce consciousness as a primitive element into physical description. (shrink)

The intuitive notion of cause carries with it the idea of compulsion. When we learn that the dynamical laws are deterministic, we give this a causal reading and imagine our actions compelled to occur by conditions laid down at the beginning of the universe. Hume famously argued that this idea of compulsion is borrowed from experience and illegitimately projected onto regularities in the world. Exploiting the interventionist analysis of causal relations, together with an insight about the degeneracy of one’s epistemic (...) relations to one’s own actions, I defend a Humean position with regard to the idea of causal compulsion. Although I discuss only compulsion, a similar story could be told about the temporal directedness of causation. (shrink)

This chapter argues that Humean analyses do not provide content‐preserving reductions and non‐trivial accounts of the reference. It introduces a distinction between structure in the realm of Being and structure in the representations of Being. The chapter argues that there are good reasons not to expect content‐preserving reductions of the modal to the non‐modal at the level of content, or useful mappings of content‐level structures into structures at the level of Being. In the rest of the chapter, the author deals (...) with the relationship between content‐level structure and structure at the level of Being. The debate between the Humean and non‐Humean should be reconceived as a debate about whether non‐Humean facts play a substantive role in the story of how beliefs about laws and chances are formed and used. (shrink)

The intuitive difference between a system that choreographs the motion of its parts in the service of goals of its own formulation and a system composed of a collection of parts doing their own thing without coordination has been shaken by now familiar examples of self-organization. There is a broad and growing presumption in parts of philosophy and across the sciences that the appearance of centralized information-processing and control in the service of system-wide goals is mere appearance, i.e., an explanatory (...) heuristic we have evolved to predict behavior, but one that will eventually get swept away in the advancing tide of self-organization. I argue that there is a distinction of central importance here, and that no adequate science of complex systems can dispense with it. (shrink)

Drawing from physics and philosophical debates, Ismael combines a set of essays on the time worn debate of symmetry from both fields.

What is time? What does it mean for time to pass? Is it possible to travel in time? What is the difference between the past and future? Until the work of Newton, these questions were purely topics of philosophical speculation. Since then we've learned a great deal about time, and its study has moved from a subject of philosophical reflection to instead became part of the subject matter of physics. This Very Short Introduction introduces readers to the current physical understanding (...) of the direction of time, from the Second Law of Thermodynamics to the emergence of complexity and life. Jenann Ismael charts the line of development in physical theory from Newton, via Einstein's Theory of Relativity, to the current day. Einstein's innovations led to a vision of time very different from the familiar time of everyday sense. In this new vision, time is one of the dimensions in which the universe is extended alongside the spatial dimensions. The universe appears as a static block of events, in which there is no more a difference between past and future than there is between east and west. Discussing the controversy and philosophical confusion which surrounded the reception of this new vision, Ismael also covers the contemporary mixture of statistical mechanics, cognitive science, and phenomenology that point the way to reconciling the familiar time of everyday sense with the vision of time presented in Einstein's theories."--Amazon.com. (shrink)

Ayahuasca is a psychoactive substance from the Amazon rainforest regions of Peru, Colombia, Ecuador, and Brazil. Although its use originated among indigenous tribes in the Amazon basin, it has become increasingly popularized in Western society through the transnational markets of spirituality and religiosity driven by globalization, Postmodernity, and new forms of religious practice. In this paper, we will overview the arrival of ayahuasca in Uruguay by way of four different groups. We will then focus on one of these groups, a (...) holistic alternative therapies center, influenced by Peruvian shamanic traditions in the design of its ceremonies. Last we will introduce a “distributed cognition” model to explain ayahuasca rituals as a system of activity. (shrink)

There’s a long history of discussion of probability in philosophy, but objective chance separated itself off and came into its own as a topic with the advent of a physical theory - quantum mechanics - in which chances play a central, and apparently ineliminable, role. In 1980 David Lewis wrote a paper pointing out that a very broad class of accounts of the nature of chance apparently lead to a contradiction when combined with a principle that expresses the role of (...) chance in guiding belief. There is still no settled agreement on the proper response to the Lewis problem. At the time he wrote the article, Lewis despaired of a solution, but, although he never achieved one that satisfied him completely, by 1994, due to work primarily by Thau and Hall, he had come to think the problem could be disarmed if we fudged a little on the meaning of ‘chance’. I’ll say more about this below. What I’m going to suggest, however, is that the qualification is unnecessary. The problem depends on an assumption that should be rejected, viz., that using information about chance to guide credence requires one to conditionalize on the theory of chance that one is using. I’m going to propose a general recipe for using information about chance to guide belief that does not require conditionalization on a theory of chance at any stage. Lewis’ problem doesn’t arise in this setting. (shrink)

Dennett argues that the decentralized view of human cognitive organization finding increasing support in parts of cognitive science undermines talk of an inner self. On his view, the causal underpinnings of behavior are distributed across a collection of autonomous subsystems operating without any centralized supervision. Selves are fictions contrived to simplify description and facilitate prediction of behavior with no real correlate inside the mind. Dennett often uses an analogy with termite colonies whose behavior looks organized and purposeful to the external (...) eye, but which is actually the emergent product of uncoordinated activity of separate components marching to the beat of their individual drums. I examine the cognitive organization of a system steering by an internal model of self and environment, and argue that it provides a model that lies between the image of mind as termite colony and a naïve Cartesianism that views the self as inner substance. (shrink)

Este trabajo explora el potencial de las fuentes artísticas y de los museos que las albergan para desarrollar competencias propias del pensamiento histórico entre estudiantes de Educación Secundaria. Se revisa de qué modo y hasta qué punto la normativa curricular española atiende al trabajo con estos dos elementos para enseñar a pensar históricamente, y se presentan argumentos, derivados de la Didáctica de las Ciencias Sociales y otros campos afines, sobre los beneficios de incluir prácticamente las colecciones artísticas en la educación (...) histórica. Para ejemplificar una posible vía de trabajo con metaconceptos como el de cambio y continuidad, se diseña una propuesta didáctica contextualizada en el Museo Pablo Gargallo (Zaragoza, España) que tiene por objetivo analizar críticamente cómo el arte ha reflejado, construido o desafiado determinados cánones de belleza a lo largo de la historia. (shrink)